Article
Rapid detection of CYP2D6 null alleles by long distance- and multiplex-polymerase chain reaction.
Pharmacogenetics - 1 Oct 1996
Stüven T, Griese E U, Kroemer H K, Eichelbaum M, Zanger U M
Abstract excerpt
The CYP2D6 gene on human chromosome 22 encodes a cytochrome P450 responsible for oxidative metabolism of over 30 clinically used drugs. The CYP2D6 gene is highly polymorphic with more than 20 alleles described to date. Some of these harbour loss-of-function mutations which lead to the poor metabo...
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