Article
Characterization of variant alleles of cytochrome CYP2D6 in a Spanish population.
Cell biochemistry and function - 1 Jan 2000
Menoyo Anna, del Rio Elisabeth, Baiget Montserrat
Abstract excerpt
The CYP2D6 gene codes for a P450 monooxygenase which is involved in the biotransformation of a large number of commonly prescribed drugs. Adverse drug effects and therapeutic failure can be related to abnormal CYP2D6 activity. We investigated the allele and genotype frequencies of cytochrome P4502D6 in a Spanish population to predict the prevalence of ultra-rapid and poor metabolizer phenotypes in our population...
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