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Article

Identification of a protective allele against Alzheimer disease in the APOE gene promoter.

Neuroreport - 7 Aug 2002

Beyer Kartrin, Lao José I, Gómez Milagros, Riutort Nadal, Latorre Pilar, Mate José L, Ariza Aurelio

Abstract excerpt

Alzheimer disease (AD) risk is significantly influenced by the APOE2 and APOE4 alleles. In turn, the -491AT and TH1/E47cs polymorphisms alter APOE gene expression levels. To determine whether these two alleles exert any significant effect on AD development we have analysed the genotypes of the APOE promoter -491AT and Th1/E47cs polymorphisms in 163 AD patients and 155 controls divided into three age at onset/age...

Read the complete abstract on PubMed

Topics

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Share to Aged, 80 and over
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 12167762
DOI: 10.1097/00001756-200208070-00011

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of a protective allele against Alzheimer disease in the APOE gene promoter.PMID 12167762Read ↗

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The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

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Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

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Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

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