A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

doi:10.1038/ng0198-69

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

Nature genetics - 1 Jan 1998

Bullido M J, Artiga M J, Recuero M, Sastre I, García M A, Aldudo J, Lendon C, Han S W, Morris J C, Frank A, Vázquez J, Goate A, Valdivieso F

Abstract excerpt

The epsilon4 allele of the apolipoprotein E gene (APOE) has been associated with an increased risk of developing Alzheimer's disease (AD; refs 1,2). However, it is apparent that the APOEepsilon4 allele alone is neither necessary nor sufficient to cause the disease. We have recently found three ne...

Topics

Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Dementia
Gene Frequency
Humans
Polymorphism, Genetic
Regulatory Sequences, Nucleic Acid
Risk Factors
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9425904
DOI: 10.1038/ng0198-69

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9425904-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics