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Article

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

Nature genetics - 1 Jan 1998

Bullido M J, Artiga M J, Recuero M, Sastre I, García M A, Aldudo J, Lendon C, Han S W, Morris J C, Frank A, Vázquez J, Goate A, Valdivieso F

Abstract excerpt

The epsilon4 allele of the apolipoprotein E gene (APOE) has been associated with an increased risk of developing Alzheimer's disease (AD; refs 1,2). However, it is apparent that the APOEepsilon4 allele alone is neither necessary nor sufficient to cause the disease. We have recently found three new polymorphisms within the APOE transcriptional regulatory region (M.J.A. et al., manuscript submitted) and now...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9425904
DOI: 10.1038/ng0198-69

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.PMID 9425904Read ↗

The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.Semantic proximity Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.Semantic proximity Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.Semantic proximity Read ↗

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.Semantic proximity Read ↗

Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.Semantic proximity Read ↗

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease.Semantic proximity Read ↗

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