Article
A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.
Human molecular genetics - 1 Mar 1998
Lambert J C, Pasquier F, Cottel D, Frigard B, Amouyel P, Chartier-Harlin M C
Abstract excerpt
The epsilon4 allele of the Apolipoprotein E gene (APOE), one of the main allele of APOE polymorphism, is a major risk factor for the development of Alzheimer's disease. However, several data suggest that genetic factors, within the APOE locus, may also modulate the risk associated with this polymorphism. We look for new mutations in the APOE promoter, susceptible to modify the risk associated with the APOE...
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