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Article

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.

Neuroreport - 17 Mar 1999

Laws S M, Taddei K, Martins G, Paton A, Fisher C, Clarnette R, Hallmayer J, Brooks W S, Gandy S E, Martins R N

Abstract excerpt

Recent evidence suggests that a polymorphism in the regulatory region of the apolipoprotein E gene (APOE) is associated with an increased risk for developing Alzheimer's disease (AD) independent of that conveyed by the epsilon4 allele of APOE. Previous work by our group indicated that plasma apol...

Topics

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Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
DNA
APOE gene
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 10208564
DOI: 10.1097/00001756-199903170-00038

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10208564-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.PMID 10208564Read ↗

The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.Semantic proximity Read ↗

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.Semantic proximity Read ↗

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.Semantic proximity Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.Semantic proximity Read ↗

Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.Semantic proximity Read ↗

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

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