Article
The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.
Neuroreport - 17 Mar 1999
Laws S M, Taddei K, Martins G, Paton A, Fisher C, Clarnette R, Hallmayer J, Brooks W S, Gandy S E, Martins R N
Abstract excerpt
Recent evidence suggests that a polymorphism in the regulatory region of the apolipoprotein E gene (APOE) is associated with an increased risk for developing Alzheimer's disease (AD) independent of that conveyed by the epsilon4 allele of APOE. Previous work by our group indicated that plasma apolipoprotein E (apoE) levels were elevated in AD, raising the possibility that the -491 genotype might modify AD risk by...
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