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Article

Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease.

Psychiatric genetics - 1 Dec 2005

Parker Ginny R, Cathcart Heather M, Huang Rong, Lanham Irene S, Corder Elizabeth H, Poduslo Shirley E

Abstract excerpt

Alzheimer's disease is a complex neurodegenerative disorder, characterized by progressive cognitive decline and distinct neuropathology. The apolipoprotein gene E4 allele (APOE 4) is a major risk factor for the disease. Promoter polymorphisms at -491 and -427 may also contribute to the risk. We examined the two polymorphisms in 178 Alzheimer's patients and 141 controls. The -491AA genotype was overrepresented...

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Source

Identifiers

PMID: 16314757
DOI: 10.1097/00041444-200512000-00009

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease.PMID 16314757Read ↗

Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.Semantic proximity Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population.Semantic proximity Read ↗

Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population.Semantic proximity Read ↗

Identification of a protective allele against Alzheimer disease in the APOE gene promoter.Semantic proximity Read ↗

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

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