Article
Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease.
Human molecular genetics - 1 Sept 1998
Lambert J C, Berr C, Pasquier F, Delacourte A, Frigard B, Cottel D, Pérez-Tur J, Mouroux V, Mohr M, Cécyre D, Galasko D, Lendon C, Poirier J, Hardy J, Mann D, Amouyel P, Chartier-Harlin M C
Abstract excerpt
Possession of the apolipoprotein E (APOE) epsilon4 allele is the most frequently associated genetic susceptibility factor for Alzheimer's disease (AD). Recently, new polymorphisms in the regulatory region of the APOE gene have been described. We analysed the effects of three of these mutations (-...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Brain
- Case-Control Studies
- Female
- Gene Expression
- Heterozygote
- Humans
- Male
- Mutation
- Odds Ratio