Article
Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.
Human molecular genetics - 1 Nov 1998
Artiga M J, Bullido M J, Frank A, Sastre I, Recuero M, García M A, Lendon C L, Han S W, Morris J C, Vázquez J, Goate A, Valdivieso F
Abstract excerpt
While the straightepsilon4 allele of apolipoprotein E ( APOE, gene; ApoE, protein) is widely accepted as a major genetic risk factor for the late onset form of Alzheimer's disease (AD), recent evidence points to variations in ApoE levels as another important factor. We have previously reported that a common variant in the regulatory region of APOE (-491A) is associated with risk for late onset AD. In this report...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.