Article
Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.
Human molecular genetics - 1 Nov 1998
Artiga M J, Bullido M J, Frank A, Sastre I, Recuero M, García M A, Lendon C L, Han S W, Morris J C, Vázquez J, Goate A, Valdivieso F
Abstract excerpt
While the straightepsilon4 allele of apolipoprotein E ( APOE, gene; ApoE, protein) is widely accepted as a major genetic risk factor for the late onset form of Alzheimer's disease (AD), recent evidence points to variations in ApoE levels as another important factor. We have previously reported th...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Gene Expression Regulation
- Gene Frequency
- Genes
- Genotype
- Haplotypes
- Humans
- Middle Aged
- Polymorphism, Genetic
- Promoter Regions, Genetic