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Article

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer's disease.

Neuroscience letters - 25 Sept 2018

Bratosiewicz-Wasik Jolanta, Liberski Pawel P, Peplonska Beata, Styczynska Maria, Smolen-Dzirba Joanna, Cycon Mariusz, Wasik Tomasz J

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a complex aetiology. The ε4 allel of the apolipoprotein E gene (APOE) is the only confirmed genetic risk factor for the development of AD. In addition, polymorphisms at the promoter region of the APOE gene are assumed to modulate the susceptibility to AD by their different affinity to the transcription factors thus affecting the...

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Source

Identifiers

PMID: 29990559
DOI: 10.1016/j.neulet.2018.07.010

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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