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Article

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.

The Journal of biological chemistry - 27 Sept 2002

Zipper Laurie M, Mulcahy R Timothy

Abstract excerpt

Transactivation of phase II detoxification enzymes and antioxidant proteins is mediated by the Cap'N'Collar transcription factor, Nrf2, which is sequestered in the cytoplasm by the actin-binding protein Keap1. Mutation of a conserved serine (S104A) within the Keap1 BTB/POZ domain disrupts Keap1 dimerization and eliminates the ability of Keap1 to sequester Nrf2 in the cytoplasm and repress Nrf2 transactivation....

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PMID: 12145307
DOI: 10.1074/jbc.M206530200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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