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Article

Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response.

Molecular and cellular biology - 1 Nov 2007

Tong Kit I, Padmanabhan Balasundaram, Kobayashi Akira, Shang Chengwei, Hirotsu Yosuke, Yokoyama Shigeyuki, Yamamoto Masayuki

Abstract excerpt

Nrf2 is the regulator of the oxidative/electrophilic stress response. Its turnover is maintained by Keap1-mediated proteasomal degradation via a two-site substrate recognition mechanism in which two Nrf2-Keap1 binding sites form a hinge and latch. The E3 ligase adaptor Keap1 recognizes Nrf2 through its conserved ETGE and DLG motifs. In this study, we examined how the ETGE and DLG motifs bind to Keap1 in a very...

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Identifiers

PMID: 17785452
DOI: 10.1128/MCB.00753-07
PMCID: PMC2169061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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