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Article

Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.

Cancer research - 1 Mar 2011

Suzuki Takafumi, Maher Jonathan, Yamamoto Masayuki

Abstract excerpt

Under homeostatic conditions, Keap1 constitutively mediates the proteasomal degradation Nrf2. However, tertiary changes in Keap1 in response to the cellular environment allow for liberation of Nrf2 to transcriptionally regulate downstream cytoprotective genes that aid in cell survival. KEAP1/NRF2 somatic mutations causing constitutive NRF2 activation have been estimated to occur in approximately 25% of human lung...

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Source

Identifiers

PMID: 21177379
DOI: 10.1158/0008-5472.CAN-10-2939

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.PMID 21177379Read ↗

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.Semantic proximity Read ↗

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activationSemantic proximity Read ↗

<i>KEAP1</i> mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancerSemantic proximity Read ↗

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