Article

Z-REX uncovers a bifurcation in function of Keap1 paralogs

2022-10-12

Abstract excerpt

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-à-vis off-target, modifications. By combining bolus dosing, knockdown, and Z-REX—a tool investigating on-target/on-pathway electrophile signaling, we document that electrophile labeling of one zebrafish-Keap1-paralog (zKeap1b) stimulates Nrf2-driven antioxidant response (AR) signaling (like t...

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Literature Corpus work: df47cd42-ab3a-5e5e-90a4-bef81c1b2428
DOI: 10.1101/2022.10.10.511579

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