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Article

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

Science (New York, N.Y.) - 26 Jul 2002

Cha Rita S, Kleckner Nancy

Abstract excerpt

Budding yeast Mec1, homolog of mammalian ATR, is an essential protein that mediates S-phase checkpoint responses and meiotic recombination. Elimination of Mec1 function leads to genomewide fork stalling followed by chromosome breakage. Breaks do not result from stochastic collapse of stalled forks or other incidental lesions; instead, they occur in specific regions of the genome during a G2 chromosomal...

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Source

Identifiers

PMID: 12142538
DOI: 10.1126/science.1071398

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.PMID 12142538Read ↗

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ATR signalling: more than meeting at the forkSemantic proximity Read ↗

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

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ATR promotes genome instability via CENP-A eviction from centromeres under replication stressSemantic proximity Read ↗

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