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Article

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.

Current biology : CB - 8 Apr 1999

Clarke D J, Segal M, Mondésert G, Reed S I

Abstract excerpt

In most eukaryotic cells, DNA replication is confined to S phase of the cell cycle [1]. During this interval, S-phase checkpoint controls restrain mitosis until replication is complete [2]. In budding yeast, the anaphase inhibitor Pds1p has been associated with the checkpoint arrest of mitosis when DNA is damaged or when mitotic spindles have formed aberrantly [3] [4], but not when DNA replication is blocked with...

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Identifiers

PMID: 10209118
DOI: 10.1016/s0960-9822(99)80163-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.PMID 10209118Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).Semantic proximity Read ↗

Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.Semantic proximity Read ↗

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase.Semantic proximity Read ↗

G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.Semantic proximity Read ↗

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.Semantic proximity Read ↗

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Semantic proximity Read ↗

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Semantic proximity Read ↗

Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.Semantic proximity Read ↗

S-phase checkpoint activity and function throughout the cell cycleSemantic proximity Read ↗

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