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Article

Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast.

The EMBO journal - 9 Aug 2006

Raveendranathan Miruthubashini, Chattopadhyay Sharbani, Bolon Yung-Tsi, Haworth Justin, Clarke Duncan J, Bielinsky Anja-Katrin

Abstract excerpt

The S-phase checkpoint kinases Mec1 and Rad53 in the budding yeast, Saccharomyces cerevisiae, are activated in response to replication stress that induces replication fork arrest. In the absence of a functional S-phase checkpoint, stalled replication forks collapse and give rise to chromosome breakage. In an attempt to better understand replication dynamics in S-phase checkpoint mutants, we developed a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Fungal

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Share to Intracellular Signaling Peptides and Proteins

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Identifiers

PMID: 16888628
DOI: 10.1038/sj.emboj.7601251
PMCID: PMC1538557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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