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Article

Rif1 and Exo1 regulate the genomic instability following telomere losses.

Aging cell - 1 Jun 2016

Xue Yuan, Marvin Marcus E, Ivanova Iglika G, Lydall David, Louis Edward J, Maringele Laura

Abstract excerpt

Telomere attrition is linked to cancer, diabetes, cardiovascular disease and aging. This is because telomere losses trigger further genomic modifications, culminating with loss of cell function and malignant transformation. However, factors regulating the transition from cells with short telomeres, to cells with profoundly altered genomes, are little understood. Here, we use budding yeast engineered to lack...

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Identifiers

PMID: 27004475
DOI: 10.1111/acel.12466
PMCID: PMC4854909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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