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Article

ATR signalling: more than meeting at the fork

27 May 2011

Abstract excerpt

Preservation of genome integrity via the DNA-damage response is critical to prevent disease. ATR (ataxia telangiectasia mutated- and Rad3-related) is essential for life and functions as a master regulator of the DNA-damage response, especially during DNA replication. ATR controls and co-ordinates DNA replication origin firing, replication fork stability, cell cycle checkpoints and DNA repair. Since its...

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PMID: 21615334
DOI: 10.1042/bj20102162

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