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Article

Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks.

EMBO reports - 1 Sept 2018

Hiraga Shin-Ichiro, Monerawela Chandre, Katou Yuki, Shaw Sophie, Clark Kate Rm, Shirahige Katsuhiko, Donaldson Anne D

Abstract excerpt

Despite its evolutionarily conserved function in controlling DNA replication, the chromosomal binding sites of the budding yeast Rif1 protein are not well understood. Here, we analyse genome-wide binding of budding yeast Rif1 by chromatin immunoprecipitation, during G1 phase and in S phase with replication progressing normally or blocked by hydroxyurea. Rif1 associates strongly with telomeres through interaction...

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Identifiers

PMID: 30104203
DOI: 10.15252/embr.201846222
PMCID: PMC6123642

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