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Article

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects.

Science (New York, N.Y.) - 26 Jul 2002

Sogo José M, Lopes Massimo, Foiani Marco

Abstract excerpt

Checkpoint-mediated control of replicating chromosomes is essential for preventing cancer. In yeast, Rad53 kinase protects stalled replication forks from pathological rearrangements. To characterize the mechanisms controlling fork integrity, we analyzed replication intermediates formed in response to replication blocks using electron microscopy. At the forks, wild-type cells accumulate short single-stranded...

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PMID: 12142537
DOI: 10.1126/science.1074023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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