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Article

Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells.

Molecular cell - 7 Jan 2005

Cotta-Ramusino Cecilia, Fachinetti Daniele, Lucca Chiara, Doksani Ylli, Lopes Massimo, Sogo José, Foiani Marco

Abstract excerpt

The replication checkpoint coordinates the cell cycle with DNA replication and recombination, preventing genome instability and cancer. The budding yeast Rad53 checkpoint kinase stabilizes stalled forks and replisome-fork complexes, thus preventing the accumulation of ss-DNA regions and reversed forks at collapsed forks. We searched for factors involved in the processing of stalled forks in HU-treated rad53...

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Identifiers

PMID: 15629726
DOI: 10.1016/j.molcel.2004.11.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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