Article
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
Nucleic acids research - 16 Nov 2015
Somyajit Kumar, Saxena Sneha, Babu Sharath, Mishra Anup, Nagaraju Ganesh
Abstract excerpt
Mammalian RAD51 paralogs are implicated in the repair of collapsed replication forks by homologous recombination. However, their physiological roles in replication fork maintenance prior to fork collapse remain obscure. Here, we report on the role of RAD51 paralogs in short-term replicative stress devoid of DSBs. We show that RAD51 paralogs localize to nascent DNA and common fragile sites upon replication fork...
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