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Article

p53 Monitors replication fork regression by binding to "chickenfoot" intermediates.

The Journal of biological chemistry - 30 Dec 2005

Subramanian Deepa, Griffith Jack D

Abstract excerpt

The tumor suppressor protein, p53, utilizes multiple mechanisms to ensure faithful transmission of the genome including regulation of DNA replication, repair, and recombination. Monitoring these pathways may involve direct binding of p53 to the DNA intermediates of these processes. In this study, we generated templates resembling stalled replication forks and utilized electron microscopy to examine p53...

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Identifiers

PMID: 16204246
DOI: 10.1074/jbc.M506348200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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