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Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

Molecular cell - 7 Sept 2017

Kolinjivadi Arun Mouli, Sannino Vincenzo, De Antoni Anna, Zadorozhny Karina, Kilkenny Mairi, Técher Hervé, Baldi Giorgio, Shen Rong, Ciccia Alberto, Pellegrini Luca, Krejci Lumir, Costanzo Vincenzo

Abstract excerpt

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms underlying this process, we isolated Xenopus laevis Brca2. We demonstrated that Brca2 protein prevents single-stranded DNA gap accumulation at replication fork junctions and behind them by promoting Rad51 binding to replicating DNA. Without Brca2, forks with...

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Identifiers

PMID: 28757209
DOI: 10.1016/j.molcel.2017.07.001
PMCID: PMC5594205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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