Article

Replication intermediate architecture reveals the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cells

2020-10-12

Abstract excerpt

DNA lesions in S phase threaten genome stability. The DNA damage tolerance (DDT) pathways overcome these obstacles and allow completion of DNA synthesis by the use of specialised translesion (TLS) DNA polymerases or through recombination-related processes. However, how these mechanisms coordinate with each other and with bulk replication remain elusive. To address these issues, we monitored the variation of replic...

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Literature Corpus work: d55b141f-4437-5ca5-b6a6-40a6c65a9b22
DOI: 10.1101/2020.10.12.336107

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