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Article

Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism.

Cell - 11 Jul 1997

Zou H, Rothstein R

Abstract excerpt

The Holliday junction recombination intermediate, an X-shaped DNA molecule (xDNA), was analyzed at rDNA in mitotically growing yeast. In wild-type cells, xDNA is only detected at S phase, suggesting that recombination is stimulated to repair replication-related lesions. A search for mutations that increase the level of xDNA uncovered a gene encoding a subunit of DNA polymerase alpha. Systematic examination of...

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PMID: 9230305
DOI: 10.1016/s0092-8674(00)80316-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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