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Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier.

Nucleic acids research - 1 Aug 2011

Sofueva Sevil, Osman Fekret, Lorenz Alexander, Steinacher Roland, Castagnetti Stefania, Ledesma Jennifer, Whitby Matthew C

Abstract excerpt

Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death. What determines whether a DSB is repaired accurately or inaccurately is currently unclear. We provide evidence that suggests that perturbing replication by a...

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Identifiers

PMID: 21576223
DOI: 10.1093/nar/gkr340
PMCID: PMC3159475

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