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Article

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

2 Mar 2015

Abstract excerpt

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomerase poisons, DNA synthesis inhibitors, interstrand cross-linking inducers, and base-damaging agents. We used electron microscopy to visualize fork architecture under...

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PMID: 25733714
DOI: 10.1083/jcb.201406099

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