Article
The DNA replication checkpoint response stabilizes stalled replication forks.
Nature - 2 Aug 2001
Lopes M, Cotta-Ramusino C, Pellicioli A, Liberi G, Plevani P, Muzi-Falconi M, Newlon C S, Foiani M
Abstract excerpt
In response to DNA damage and blocks to replication, eukaryotes activate the checkpoint pathways that prevent genomic instability and cancer by coordinating cell cycle progression with DNA repair. In budding yeast, the checkpoint response requires the Mec1-dependent activation of the Rad53 protein kinase. Active Rad53 slows DNA synthesis when DNA is damaged and prevents firing of late origins of replication....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.