Article
MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system.
Journal of bacteriology - 1 Aug 2002
Kane Colleen D, Schuch Raymond, Day William A, Maurelli Anthony T
Abstract excerpt
The mxi-spa locus on the virulence plasmid of Shigella flexneri encodes components of the type III secretion system. mxiE, a gene within this locus, encodes a protein that is homologous to the AraC/XylS family of transcriptional regulators, but currently its role in pathogenesis remains undefined. We characterized the virulence phenotype of a nonpolar mxiE mutant and found that this mutant retained the ability to...
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