Article
Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri.
Microbiology (Reading, England) - 1 Mar 2005
Gall Tony Le, Mavris Maria, Martino Maria Celeste, Bernardini Maria Lina, Denamur Erick, Parsot Claude
Abstract excerpt
Proteins directly involved in entry and dissemination of Shigella flexneri into epithelial cells are encoded by a virulence plasmid of 200 kb. A 30-kb region (designated the entry region) of this plasmid encodes components of a type III secretion (TTS) apparatus, substrates of this apparatus and their dedicated chaperones. During growth of bacteria in broth, expression of these genes is induced at 37 degrees C...
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