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Article

MxiC is secreted by and controls the substrate specificity of the <i>Shigella flexneri</i> type III secretion apparatus

11 Nov 2008

Abstract excerpt

Many gram-negative pathogenic bacteria use a type III secretion (T3S) system to interact with cells of their hosts. Mechanisms controlling the hierarchical addressing of needle subunits, translocators and effectors to the T3S apparatus (T3SA) are still poorly understood. We investigated the function of MxiC, the member of the YopN/InvE/SepL family in the Shigella flexneri T3S system. Inactivation of mxiC led...

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Identifiers

PMID: 19017268
DOI: 10.1111/j.1365-2958.2008.06537.x

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MxiC is secreted by and controls the substrate specificity of the <i>Shigella flexneri</i> type III secretion apparatusPMID 19017268Read ↗

IpgD, a protein secreted by the type III secretion machinery of <i>Shigella flexneri</i> , is chaperoned by IpgE and implicated in entry focus formationSemantic proximity Read ↗

MxiA, MxiC and IpaD Regulate Substrate Selection and Secretion Mode in the T3SS of Shigella flexneri.Semantic proximity Read ↗

A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri.Semantic proximity Read ↗

A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.Semantic proximity Read ↗

The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus.Semantic proximity Read ↗

IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.Semantic proximity Read ↗

MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system.Semantic proximity Read ↗

Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors.Semantic proximity Read ↗

Steps for Shigella Gatekeeper Protein MxiC Function in Hierarchical Type III Secretion Regulation.Semantic proximity Read ↗

A translocation-competent pore is required for <i>Shigella flexneri</i> to escape from the double membrane vacuole during intercellular spreadSemantic proximity Read ↗

Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins.Semantic proximity Read ↗

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures.Semantic proximity Read ↗

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