Article
Molecular Pathogenesis of<i>Shigella</i>spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion
1 Jan 2008
Abstract excerpt
Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research performed over the last 25 years revealed that a type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella flexneri. The T3SS determines the interactions of S. flexneri with intestinal cells by consecutively...