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Article

Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins.

Journal of bacteriology - 1 Jul 2002

Magdalena Juana, Hachani Abderrahman, Chamekh Mustapha, Jouihri Noureddine, Gounon Pierre, Blocker Ariel, Allaoui Abdelmounaaïm

Abstract excerpt

Type III secretion systems (TTSS) are essential virulence determinants of many gram-negative bacteria and serve, upon physical contact with target cells, to translocate bacterial proteins directly across eukaryotic cell membranes. The Shigella TTSS is encoded by the mxi/spa loci located on its virulence plasmid. By electron microscopy secretons are visualized as tripartite with an external needle, a transmembrane...

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Identifiers

PMID: 12057936
DOI: 10.1128/JB.184.13.3433-3441.2002
PMCID: PMC135143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins.PMID 12057936Read ↗

The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus.Semantic proximity Read ↗

MxiC is secreted by and controls the substrate specificity of the <i>Shigella flexneri</i> type III secretion apparatusSemantic proximity Read ↗

A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.Semantic proximity Read ↗

Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells.Semantic proximity Read ↗

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures.Semantic proximity Read ↗

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.Semantic proximity Read ↗

Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors.Semantic proximity Read ↗

MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system.Semantic proximity Read ↗

Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificitySemantic proximity Read ↗

Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton.Semantic proximity Read ↗

MxiA, MxiC and IpaD Regulate Substrate Selection and Secretion Mode in the T3SS of Shigella flexneri.Semantic proximity Read ↗

IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.Semantic proximity Read ↗

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