IpgD, a protein secreted by the type III secretion machinery of <i>Shigella flexneri</i> , is chaperoned by IpgE and implicated in entry focus formation

Abstract excerpt

Invasion of epithelial cells by Shigella flexneri involves entry and intercellular dissemination. Entry of bacteria into non-phagocytic cells requires the IpaA-D proteins that are secreted by the Mxi-Spa type III secretion machinery. Type III secretion systems are found in several Gram-negative pathogens and serve to inject bacterial effector proteins directly into the cytoplasm of host cells. In this study, we...

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