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Article

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures.

Molecular microbiology - 1 Apr 1995

Parsot C, Ménard R, Gounon P, Sansonetti P J

Abstract excerpt

Genes required for entry of Shigella flexneri into epithelial cells in vitro are clustered in two adjacent loci, one of which encodes secretory proteins, the IpaA-D proteins, and the other their dedicated secretion apparatus, the Mxi-Spa translocon. Ipa secretion, which is induced upon contact of bacteria with epithelial cells, is prevented during growth in vitro. Here, we show that ipaB and ipaD mutations lead...

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Identifiers

PMID: 7565091
DOI: 10.1111/j.1365-2958.1995.tb02301.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures.PMID 7565091Read ↗

Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins.Semantic proximity Read ↗

MxiC is secreted by and controls the substrate specificity of the <i>Shigella flexneri</i> type III secretion apparatusSemantic proximity Read ↗

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.Semantic proximity Read ↗

IpgD, a protein secreted by the type III secretion machinery of <i>Shigella flexneri</i> , is chaperoned by IpgE and implicated in entry focus formationSemantic proximity Read ↗

IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri.Semantic proximity Read ↗

A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.Semantic proximity Read ↗

Disulfide oxidoreductase activity of Shigella flexneri is required for release of Ipa proteins and invasion of epithelial cells.Semantic proximity Read ↗

A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri.Semantic proximity Read ↗

MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system.Semantic proximity Read ↗

Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins.Semantic proximity Read ↗

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.Semantic proximity Read ↗

SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion.Semantic proximity Read ↗

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