Article
A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.
Molecular microbiology - 1 Nov 1999
Schuch R, Sandlin R C, Maurelli A T
Abstract excerpt
Invasion and intercellular spread are hallmarks of Shigella pathogenicity. Invasion of the eukaryotic cell cytosol requires a type III secretion system (Mxi-Spa) and its cognate set of secreted Ipa invasins. Once intracellular, the IcsA protein directs a form of actin-based motility that helps to drive intracellular bacterial movement, formation of cellular protrusions and cell-to-cell spread. Work in our...
Topics
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Cell Line
- Cell Wall
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Lipoproteins
- Mutation
- Proton-Translocating ATPases
- Shigella flexneri
- Vacuolar Proton-Translocating ATPases