Article
A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri.
Molecular microbiology - 1 Jun 2005
Parsot Claude, Ageron Elisabeth, Penno Christophe, Mavris Maria, Jamoussi Kais, d'Hauteville Hélène, Sansonetti Philippe, Demers Brigitte
Abstract excerpt
Bacteria of Shigella spp. are responsible for shigellosis in humans and use a type III secretion (TTS) system to enter epithelial cells and trigger apoptosis in macrophages. Transit of translocator and effector proteins through the TTS apparatus is activated upon contact of bacteria with host cells. Transcription of approximately 15 genes encoding effectors is regulated by the TTS apparatus activity and...
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