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Article

Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens.

Infection and immunity - 1 Jun 1991

Andrews G P, Hromockyj A E, Coker C, Maurelli A T

Abstract excerpt

A bank of over 4,200 lacZ protein fusions in Shigella flexneri 2a was screened for fusions to temperature-regulated promoters. One mutant, BS260, was completely noninvasive on HeLa cells and mapped to a region on the 220-kb virulence plasmid in which we had previously localized several avirulent...

Topics

Animals
Antigens, Bacterial
Blotting, Western
Enzyme-Linked Immunosorbent Assay
Escherichia coli
Genes, Bacterial
HeLa Cells
Humans
Operon
Phenotype
Plasmids
Rabbits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Shigella flexneri

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 2037361
DOI: 10.1128/iai.59.6.1997-2005.1991
PMCID: PMC257956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2037361-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens.PMID 2037361Read ↗

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