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Article

Response of the phiX174 am3, cs70 transgene to acute and chronic ENU exposure: implications for protocol design.

Mutation research - 25 Jul 2002

Cosentino Lidia, Malling Heinrich V, Heddle John A

Abstract excerpt

Studies of other transgenic assays have shown that time after treatment is a very important variable in the analysis of mutation frequencies but that eventually a plateau frequency is reached, indicating that the mutations are neutral. This neutrality is very important for the design of both experiments and testing protocols. Here we show that the phiX174 am3, cs70 transgene gives qualitatively similar results to...

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PMID: 12113762
DOI: 10.1016/s1383-5718(02)00078-5

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