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Article

The accumulation and persistence of somatic mutations in vivo.

Mutagenesis - 1 May 1994

Tao K S, Heddle J A

Abstract excerpt

Mutant frequencies at the native Dlb-1 and the lacI transgene reach a plateau within 1 week of mutagenesis in the small intestine of mice. This indicates that these mutations are selectively neutral and should accumulate additively. In a test with three mutagens, one potent (ethylnitrosourea) and two weak (1,2-dimethylhydrazine and methyl methanesulphonate), ten weekly treatments induced ten times the frequency...

Topics

1,2-Dimethylhydrazine
Animals
Dimethylhydrazines
Ethylnitrosourea
Female
Intestine, Small
Lac Operon
Male
Methyl Methanesulfonate
Mice
Mice, Inbred C57BL
Mice, Transgenic

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Mutagenesis

Mutagenicity Tests

Mutation

Time Factors

Source

Identifiers

PMID: 7934958
DOI: 10.1093/mutage/9.3.187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7934958-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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