Article
Effects of extended chronic exposures on endogenous and transgenic loci: implications for low-dose extrapolations.
Environmental and molecular mutagenesis - 1 Jan 1999
Cosentino L, Heddle J A
Abstract excerpt
Although transgenic and endogenous loci generally respond alike to acute mutagenic exposures, those loci that have been tested respond differently to daily or continuous exposures. During chronic exposures, the transgenes accumulate mutations linearly, whereas the endogenous loci are less mutable initially but later accumulate mutations at an accelerating rate. The result is a reverse dose rate effect in which...
Topics
- Animals
- Dose-Response Relationship, Drug
- Ethylnitrosourea
- Male
- Mice
- Mice, Transgenic
- Mutagenicity Tests
- Mutagens
- Mutation
- Transgenes