A test for neutrality of mutations of the lacZ transgene.

doi:10.1002/(SICI)1098-2280(1996)28:4<313::AID-EM3>3.0.CO;2-C

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Article

A test for neutrality of mutations of the lacZ transgene.

Environmental and molecular mutagenesis - 1 Jan 1996

Cosentino L, Heddle J A

Abstract excerpt

Neutral mutations are stable alterations in DNA that are neither beneficial nor damaging to the cell. Once a mutation is fixed in the DNA, the mutant frequency should increase to its maximum and plateau thereafter, provided that enough expression time is given. Evidence has been obtained indicati...

Topics

Animals
Ethylnitrosourea
Female
Genetic Techniques
Intestine, Small
Male
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Mice, Transgenic
Mutagenesis
Mutagenicity Tests
Mutagens
Mutation
Time Factors
Transgenes
beta-Galactosidase

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