Article
Differential mutation of transgenic and endogenous loci in vivo.
Mutation research - 6 Nov 2000
Cosentino L, Heddle J A
Abstract excerpt
Although chemicals usually induce very similar frequencies of mutations in transgenes and endogenous genes in vivo when given acutely, chronic exposure to N-ethyl-N-nitrosourea (ENU) produced a more complex pattern in which the endogenous locus was spared many mutations. Here, we demonstrate that the effect is neither ENU-specific nor locus-specific, and thus, may be important in the extrapolations of risk...
Topics
- Animals
- Bacterial Proteins
- Benzo(a)pyrene
- Chromosome Mapping
- Escherichia coli Proteins
- Ethylnitrosourea
- Hypoxanthine Phosphoribosyltransferase
- Lac Operon
- Lac Repressors
- Mice
- Mice, Transgenic
- Mutation