Article
Three origins of phiX174 am3 revertants in transgenic cell culture.
Environmental and molecular mutagenesis - 1 Jan 2003
Malling Heinrich V, Delongchamp Robert R, Valentine Carrie R
Abstract excerpt
Transgenic systems for measuring mammalian mutagenesis often use recoverable viral vectors. We hypothesize that mutations in these transgenic systems can arise from three different origins of DNA damage and replication errors and that these three origins of mutations (in vivo, ex vivo, and in vitro) can be differentiated in the PhiX174 am3, cs70 single burst assay (SBA) on the basis of burst size (BS). In vivo...
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