Comparison of somatic mutation in a transgenic versus host locus.

doi:10.1073/pnas.90.22.10681

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Article

Comparison of somatic mutation in a transgenic versus host locus.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1993

Tao K S, Urlando C, Heddle J A

Abstract excerpt

Somatic mutations can now be quantified in almost any cell type in mice carrying bacterial genes in a lambda phage shuttle vector. Mutations induced in vivo are detectable ex vivo, after packaging host-cell DNA into phage that are grown on suitable bacteria. However, the transgenic DNA differs fr...

Topics

Animals
Ethylnitrosourea
Genes
Intestines
Lectins
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutagens
Mutation
Plant Lectins
X-Rays

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