Article
Comparison of somatic mutation in a transgenic versus host locus.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1993
Tao K S, Urlando C, Heddle J A
Abstract excerpt
Somatic mutations can now be quantified in almost any cell type in mice carrying bacterial genes in a lambda phage shuttle vector. Mutations induced in vivo are detectable ex vivo, after packaging host-cell DNA into phage that are grown on suitable bacteria. However, the transgenic DNA differs from many host loci in several ways: it (i) is prokaryotic DNA, (ii) is present in multiple tandem copies, and (iii) is...
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