Article
Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo.
Environmental and molecular mutagenesis - 1 Jan 2001
Swiger R R, Cosentino L, Masumura K I, Nohmi T, Heddle J A
Abstract excerpt
The utility of any mutation assay depends on its characteristics, which are best discovered using model mutagens. To this end, we report further on the characteristics of the lambda-based gpt delta transgenic assay first described by Nohmi et al. ([1996]: Environ Mol Mutagen 28:465-470). Our studies show that the gpt transgene responds similarly to other transgenic loci, specifically lacZ and cII, after treatment...
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