Article
Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection.
The Journal of experimental medicine - 1 Jul 2002
Haks Mariëlle C, Pépin Elsa, van den Brakel Jeroen H N, Smeele Sigrid A A, Belkowski Stanley M, Kessels Helmut W H G, Krimpenfort Paul, Kruisbeek Ada M
Abstract excerpt
The immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains associated with the T cell receptor (TCR) are crucial for TCR signaling. To probe the role of the CD3gamma-ITAM in T cell development, we created knock-in mice in which the CD3gamma chain of the TCR complex is replaced by a mutant signaling-deficient CD3gamma chain, lacking the CD3gamma-ITAM. This mutation results in considerable...
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