Article
CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.
The EMBO journal - 17 Mar 1997
Dave V P, Cao Z, Browne C, Alarcon B, Fernandez-Miguel G, Lafaille J, de la Hera A, Tonegawa S, Kappes D J
Abstract excerpt
The CD3 complex found associated with the T cell receptor (TCR) is essential for signal transduction following TCR engagement. During T cell development, TCR-mediated signalling promotes the transition from one developmental stage to the next and controls whether a thymocyte undergoes positive or negative selection. The roles of particular CD3 components in these events remain unclear. Indeed, it is unknown...
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