Article
CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage.
The EMBO journal - 17 Mar 1997
Dave V P, Cao Z, Browne C, Alarcon B, Fernandez-Miguel G, Lafaille J, de la Hera A, Tonegawa S, Kappes D J
Abstract excerpt
The CD3 complex found associated with the T cell receptor (TCR) is essential for signal transduction following TCR engagement. During T cell development, TCR-mediated signalling promotes the transition from one developmental stage to the next and controls whether a thymocyte undergoes positive or...
Topics
- Animals
- CD3 Complex
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Antigen, T-Cell, gamma-delta
- Restriction Mapping
- T-Lymphocyte Subsets